Mitochondria Phenome Knowledgebase

Gene Symbol TP53
Ensembl ID ENSG00000141510 Entrez 7157
Gene Alias LFS1; TRP53; p53 Subcellular Locations Cytoplasm Mitochondria Mitochondrial-outer-membrane Nucleus
Map Position 17p13.1 Subcell PMIDs 10821866 12667443
OMIM Gene 191170 Protein Complex
Swissprot ID P04637 Swissprot Description Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13)
OMIM Disease Breast cancer (BRCA) [114480]; Colorectal cancer (CRC) [114500]; Hepatocellular carcinoma (HCC) [114550]; Li Fraumeni syndrome (LFS) [151623]; Adrenocortical carcinoma (ADCC) [202300]; Pancreatic carcinoma [260350]

Gene-Feature associations that are associated with 1 Gene

Gene OMIM Disease Phenotypic Feature Phenotype Annotation Clinical Category PMIDs
TP53 114480 Neoplasms oncologic #1734086 #2052583 #10623666 #10879542
TP53 114500 Neoplasms oncologic #1978757 #11223545 #16418264
TP53 114550 Neoplasms oncologic #8191284 #8640905 #10389750
TP53 151623 Neoplasms oncologic #1978757 #2259385 #3409256 #7614454 #7887414 #8118819 #8527048 #8649785 #8869100 #9569035 #10435620 #10484981 #10645809 #11474498 #11518751 #12200603 #12885464 #15073606 #15368100 #15390294 #16033918 #16096528 #16401470
TP53 202300 Neoplasms oncologic #8106638 #9795365
TP53 260350 Neoplasms oncologic #8494051 #8513440 #14707724
TP53 151623 Leukemia-Lymphoma lymphocytic lymphoma; histiocytic lymphoma; myeloid leukemia oncologic 1978757 2259385 3409256 8118819 8869100 16401470
TP53 151623 Connective-and-soft-tissue-neoplasms oncologic #1978757 #2259385 #3409256 #7614454 #7887414 #8118819 #8527048 #8649785 #8869100 #10435620 #11518751 #12200603 #12885464 #15073606 #15368100 #15390294 #16096528 #16401470
TP53 151623 Muscle-tissue-neoplasm oncologic #8118819 #8527048 #8649785 #10435620 #12200603 #15073606 #15390294 #16096528 #16401470
TP53 151623 Leiomyoma uterine; uterine leiomyoma; intramural leiomyomas oncologic 8527048 15073606 16401470
TP53 151623 Leiomyosarcoma retroperitoneal leiomyosarcoma oncologic 8649785 12200603 15073606
TP53 151623 Rhabdomyosarcoma synchronous rhabdomyosarcoma oncologic 8118819 10435620 15390294 16096528 16401470
TP53 151623 Sarcoma soft tissue sarcoma; rhabdomyosarcoma; osteosarcoma; osteogenic sarcoma; liposarcoma; bone sarcoma; neurofibrosarcoma oncologic 1978757 2259385 3409256 7614454 7887414 8118819 8649785 8869100 10435620 11518751 12885464 15073606 15368100 15390294 16096528 16401470
TP53 151623 Osteosarcoma telangiectatic osteosarcoma; osteogenic sarcoma; bone sarcoma oncologic 7614454 8118819 8649785 10435620 11518751 15073606 15390294
TP53 151623 Gonadal-tissue-neoplasms gonadal neoplasia; gonadal germ cell tumors; seminoma oncologic 3409256 10484981
TP53 151623 Neuroectodermal-tumors oncologic #1978757 #2259385 #10435620 #12200603
TP53 202300 Neuroectodermal-tumors oncologic #8106638 #9795365
TP53 151623 Neuroendocrine-tumors oncologic #1978757 #2259385 #10435620 #12200603
TP53 202300 Neuroendocrine-tumors oncologic #8106638 #9795365
TP53 151623 Melanoma malignant melanoma oncologic 1978757 10435620 12200603
TP53 151623 Neurilemoma oncologic 2259385
TP53 202300 Pheochromocytoma malignant pheochromocytoma; benign multiple pheochromocytoma oncologic 8106638 9795365
TP53 114480 Breast-neoplasms invasive breast carcinoma; breast cancer; carcinoma in situ; comedocarcinoma; cribriform ductal carcinoma; micropapillary ductal carcinoma oncologic 1734086 2052583 10623666 10879542
TP53 151623 Breast-neoplasms breast cancer; bilateral breast cancer; paget carcinoma; mammary tumors; malignant phyllodes tumor; intraductal carcinoma oncologic 1978757 2259385 3409256 7887414 8118819 8527048 8869100 9569035 10435620 10484981 11474498 11518751 12200603 15073606 16033918 16401470
TP53 114500 Digestive-system-neoplasms oncologic #1978757 #11223545 #16418264
TP53 114550 Digestive-system-neoplasms oncologic #8191284 #8640905 #10389750
TP53 151623 Digestive-system-neoplasms esophageal cancer oncologic #1978757 #2259385 8649785 #10645809 #11474498 #11518751 #12200603 #12885464 #15368100 #16033918 #16401470
TP53 260350 Digestive-system-neoplasms oncologic #8494051 #8513440 #14707724
TP53 114500 Colorectal-neoplasms colorectal carcinoma; colorectal intramucosal carcinomas oncologic 1978757 11223545 16418264
TP53 151623 Colorectal-neoplasms colon cancer; colon adenocarcinoma; colorectal carcinoma oncologic 1978757 2259385 11474498 12885464 16401470
TP53 151623 Stomach-neoplasms stomach carcinoma; gastric carcinoma; gastric cancer; hereditary diffuse gastric cancer; HDGC oncologic 10645809 11518751 12200603 15368100 16033918 16401470
TP53 114550 Hepatocellular-carcinoma hepatocellular carcinoma; HCC; aflatoxin B1 related carcinoma oncologic 8191284 8640905 10389750
TP53 151623 Hepatocellular-carcinoma liver tumor; hepatosarcoma; hepatocellular carcinoma; HCC; liver carcinoma oncologic 10645809 16033918
TP53 151623 Pancreatic-neoplasms pancreatic carcinoma oncologic 1978757 8649785
TP53 260350 Pancreatic-neoplasms pancreatic adenocarcinomas; pancreatic cancer oncologic 8494051 8513440 14707724
TP53 151623 Laryngeal-neoplasms carcinoma of the larynx oncologic 12200603
TP53 151623 Thyroid-neoplasms thyroid carcinoma oncologic 16401470
TP53 151623 Brain-neoplasms astrocytoma; meningeoma; choroid plexus; medulloblastoma; CNS brain tumor oncologic 1978757 2259385 3409256 7887414 8118819 8869100 9569035 10435620 10484981 11474498 12200603 15368100 16033918 16401470
TP53 151623 Lung-neoplasms lung adenocarcinoma; small cell lung carcinoma oncologic 1978757 11474498 11518751 16033918 16401470
TP53 151623 Thymoma oncologic 10484981
TP53 151623 Urogenital-neoplasms oncologic #1978757 #8869100 #9569035 #12200603 #15073606 #16033918 #16401470
TP53 151623 Endometrial-neoplasms endometrial carcinoma; endometrioid adenocarcinoma oncologic 8869100 15073606 16401470
TP53 151623 Prostatic-neoplasms prostate carcinoma; prostate cancer oncologic 1978757 12200603 16033918
TP53 151623 Renal-cell-carcinoma oncologic 9569035
TP53 114550 Digestive-system-diseases gastrointestinal #8191284 #8640905 #10389750
TP53 114550 Liver-diseases gastrointestinal #8191284 #8640905 #10389750
TP53 114550 Hepatitis subacute; progressive; viral hepatitis; chronic hepatitis gastrointestinal 8191284 8640905 10389750
TP53 114550 Liver-cirrhosis micronodular; chronic cirrhosis gastrointestinal 8191284 8640905 10389750
TP53 202300 Nervous-system-diseases neurologic #11481490 #11600572
TP53 202300 Neurologic-manifestations neurologic #11481490 #11600572
TP53 202300 Neuromuscular-manifestations neurologic #11481490 #11600572
TP53 202300 Muscle-weakness cushing syndrome feature neurologic 11481490 11600572
TP53 202300 Cardiovascular-diseases cardiovascular #11481490 #11600572
TP53 202300 Vascular-diseases cardiovascular #11481490 #11600572
TP53 202300 Hypertension cushing syndrome feature cardiovascular 11481490 11600572
TP53 151623 Hematologic-diseases hematologic #2259385
TP53 151623 Polycythemia polycythemia vera hematologic 2259385
TP53 202300 Skin-diseases dermatologic #11481490 #11600572
TP53 202300 Hair-diseases dermatologic #11481490 #11600572
TP53 202300 Hypertrichosis excessive hair growth; cushing syndrome feature dermatologic 11481490 11600572
TP53 202300 Metabolic-diseases metabolic #11481490 #11600572
TP53 202300 Obesity cushing syndrome feature metabolic 11481490 11600572
TP53 151623 Endocrine-system-diseases endocrinologic #1978757 #3409256 #7614454 #8118819 #9569035 #15390294 #16033918 #16096528 #16401470
TP53 202300 Endocrine-system-diseases endocrinologic #7966399 #8106638 #9795365 #11481490 #11600572 #15952083
TP53 151623 Adrenal-gland-diseases endocrinologic #1978757 #3409256 #7614454 #8118819 #9569035 #15390294 #16033918 #16096528 #16401470
TP53 202300 Adrenal-gland-diseases adrenal hyperfunction endocrinologic #7966399 #8106638 #9795365 11481490 11600572 #15952083
TP53 151623 Adrenal-gland-neoplasms endocrinologic #1978757 #3409256 #7614454 #8118819 #9569035 #15390294 #16033918 #16096528 #16401470
TP53 202300 Adrenal-gland-neoplasms adrenal neoplasms; adrenocortical adenomas; adrenal neoplasms; incidentaloma endocrinologic #7966399 8106638 9795365 #11481490 15952083
TP53 151623 Adrenocortical-carcinoma adrenal cortical carcinoma endocrinologic 1978757 3409256 7614454 8118819 9569035 15390294 16033918 16096528 16401470
TP53 202300 Adrenocortical-carcinoma adrenocortical carcinoma; adrenocortical adenoma; adrenocortical tumor; childhood adrenocortical tumour; ACT endocrinologic 7966399 8106638 11481490 15952083
TP53 202300 Adrenocortical-hyperfunction endocrinologic #8106638 #11481490 #11600572 #15952083
TP53 202300 Hypercortisolism cushing syndrome feature endocrinologic 8106638 15952083
TP53 202300 Hyperaldosteronism aldosteron levels elevated; primary aldosteronism endocrinologic 8106638 11481490 11600572
TP53 202300 Gonadal-disorders endocrinologic #11481490 #11600572 #15952083
TP53 202300 Sex-differentiation-disorders virilisation; virilization; precocious development of secondary masculine features; feminilization endocrinologic 11481490 11600572 15952083

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