Mitochondria Phenome Knowledgebase

Gene Symbol SDHB
Ensembl ID ENSG00000117118 Entrez 6390
Gene Alias IP; PGL4; SDH; SDH1; SDHIP Subcellular Locations Mitochondria Mitochondrial-inner-membrane
Map Position 1p36.1-p35 Subcell PMIDs 11404820
OMIM Gene 185470 Protein Complex Respiratory chain complex II (RCCII); Tricarboxylic acid cycle (TCA)
Swissprot ID P21912 Swissprot Description Succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor
OMIM Disease Paragangliomas 4 (PGL4) [115310]; Pheochromocytoma [171300]

Gene-Feature associations that are associated with 1 Gene

Gene OMIM Disease Phenotypic Feature Phenotype Annotation Clinical Category PMIDs
SDHB 115310 Neoplasms oncologic #9509062 #11404820 #12213855 #14685938 #14715873 #15371856 #15473885 #15531530 #16258955 #16304664 #16314641 #16317055 #16405730 #16472267
SDHB 171300 Neoplasms oncologic #11404820 #12000816
SDHB 115310 Connective-and-soft-tissue-neoplasms oncologic #16258955 #16317055
SDHB 115310 Lipoma angiolipomata; renal angiolipoma oncologic 16258955 16317055
SDHB 115310 Glandular-and-epithelial-neoplasms oncologic #9509062 #11404820
SDHB 115310 Squamous-cell-neoplasms squamous cell carcinoma; cervical squamous carcinoma of the uterus oncologic 9509062 11404820
SDHB 115310 Neuroectodermal-tumors oncologic #9509062 #11404820 #12213855 #14685938 #14715873 #15371856 #15473885 #15531530 #16258955 #16304664 #16314641 #16317055 #16405730 #16472267
SDHB 171300 Neuroectodermal-tumors oncologic #11404820 #12000816
SDHB 115310 Neuroendocrine-tumors oncologic #9509062 #11404820 #12213855 #14685938 #14715873 #15371856 #15473885 #15531530 #16258955 #16304664 #16314641 #16317055 #16405730 #16472267
SDHB 171300 Neuroendocrine-tumors oncologic #11404820 #12000816
SDHB 115310 Paraganglioma multiple; head; neck; retroperitoneum; abdominal; urinary bladder; para aortic tumours; heart; carotid body tumors; extra adrenal sympathetic ganglia paragangliomas; glomus tumors; Zuckerkandl organ paraganglioma; high risk factor for malignancy; poor prognosis oncologic 9509062 11404820 12213855 14685938 14715873 15371856 15473885 15531530 16258955 16304664 16314641 16317055 16405730 16472267
SDHB 115310 Pheochromocytoma glomus jugularis; adrenal medulla pheochromocytomas; medullary paraganglioma; catecholamine secreting paraganglioma oncologic 9509062 11404820 12213855 15371856 15473885 16304664 16314641 16317055 16405730 16472267
SDHB 171300 Pheochromocytoma isolated pheochromocytomas; bilateral oncologic 11404820 12000816
SDHB 115310 Thyroid-neoplasms partly fibrotic nonencapsulated tumour; thyroid gland tumour; paraganglioma of the thyroid gland; thyroid paraganglioma; benign thyroid nodules oncologic 16317055
SDHB 115310 Urogenital-neoplasms oncologic #14685938
SDHB 115310 Renal-cell-carcinoma clear cell carcinoma; renal tumors; kidney cancers; renal cell carcinoma; RCC oncologic 14685938
SDHB 115310 Digestive-system-diseases gastrointestinal #14715873 #16304664 #16472267
SDHB 115310 Digestive-system-abnormalities diverticulosis; severe diverticular disease; inflammatory areas gastrointestinal 16472267
SDHB 115310 Gastrointestinal-diseases gastrointestinal #14715873 #16472267
SDHB 115310 Gastrointestinal-hemorrhage gastrointestinal bleeding; duodenal ulceration; duodenal ulcers; bleeding duodenal ulcers gastrointestinal 14715873 16472267
SDHB 115310 Abdominal-pain gastrointestinal 16304664
SDHB 115310 Respiratory-tract-diseases respiratory #15473885 #16304664
SDHB 115310 Lung-diseases respiratory #15473885
SDHB 115310 Pulmonary-edema paroxysmal pulmonary oedema respiratory 15473885
SDHB 115310 Respiration-disorders respiratory #16304664
SDHB 115310 Respiratory-insufficiency sudden dyspnea; dyspnea respiratory 16304664
SDHB 115310 Nervous-system-diseases neurologic #9509062 #11404820 #12213855 #14715873 #15371856 #15473885 #16304664 #16317055 #16405730
SDHB 115310 Central-nervous-system-diseases neurologic #9509062 #11404820 #12213855 #14715873 #15371856 #15473885 #16304664 #16317055
SDHB 115310 Brain-diseases neurologic #9509062 #11404820 #12213855 #14715873 #15371856 #15473885 #16304664 #16317055
SDHB 115310 Cerebrovascular-disorders neurologic #9509062 #11404820
SDHB 115310 Intracranial-hemorrhages cerebral haemorrhage; mild spastic quadriparesis due to cerebral haemorrhage neurologic 9509062 11404820
SDHB 115310 Headache-disorders throbbing headache; forceful attacks neurologic 12213855 14715873 15371856 15473885 16304664 16317055
SDHB 115310 Cranial-nerve-diseases neurologic #16405730
SDHB 115310 Vocal-cord-paralysis vocal cord palsy; vagal paraganglioma related neurologic 16405730
SDHB 115310 Neurologic-manifestations neurologic #16304664 #16405730
SDHB 115310 Neuromuscular-manifestations neurologic #16405730
SDHB 115310 Muscular-atrophy muscle wasting; trapezius muscle wasting neurologic 16405730
SDHB 115310 Hearing-disorders diminished hearing neurologic 16405730
SDHB 115310 Tinnitus pulsatile tinnitus neurologic 16405730
SDHB 115310 Vertigo positional vertigo; dizziness neurologic 16304664 16405730
SDHB 115310 Cardiovascular-diseases cardiovascular #9509062 #11404820 #12213855 #14715873 #15371856 #15473885 #16258955 #16304664 #16317055 #16405730 #16472267
SDHB 115310 Heart-diseases cardiovascular #12213855 #14715873 #15473885 #16304664 #16317055
SDHB 115310 Arrhythmia arrythmias; palpitations; tachycardia cardiovascular 12213855 14715873 15473885 16304664 16317055
SDHB 115310 Vascular-diseases cardiovascular #9509062 #11404820 #12213855 #14715873 #15371856 #15473885 #16258955 #16304664 #16317055 #16405730 #16472267
SDHB 115310 Hypertension secondary hypertension; hypertensive crisis cardiovascular 9509062 11404820 12213855 14715873 15371856 15473885 16258955 16304664 16317055 16405730 16472267
SDHB 115310 Myocardial-ischemia ischemic heart disease cardiovascular 16317055 #16472267
SDHB 115310 Coronary-disease coronary artery disease; coronary artery bypass surgery cardiovascular 16472267
SDHB 115310 Skin-diseases dermatologic #12213855 #14715873 #15371856 #15473885
SDHB 115310 Sweat-gland-diseases dermatologic #12213855 #14715873 #15371856 #15473885
SDHB 115310 Hyperhidrosis diaphoresis; sweating on minimal exertion; truncal sweating dermatologic 12213855 14715873 15371856 15473885
SDHB 115310 Paleness pallor dermatologic 14715873
SDHB 115310 Metabolic-diseases metabolic #16472267
SDHB 115310 Dyslipidemias metabolic #16472267
SDHB 115310 Hyperlipidemia metabolic 16472267
SDHB 115310 Endocrine-system-diseases endocrinologic #9509062 #11404820 #16314641 #16317055 #16405730
SDHB 115310 Adrenal-gland-diseases endocrinologic #9509062 #11404820 #16314641 #16317055 #16405730
SDHB 115310 Adrenal-gland-neoplasms adrenal medulla pheochromocytomas; adrenal carcinoma; pheochromocytoma of the adrenal gland; adrenal gland tumors endocrinologic 9509062 11404820 16314641 16317055 16405730
SDHB 115310 Thyroid-diseases endocrinologic #9509062 #11404820
SDHB 115310 Goiter nodular goitre; thyroid gland goitre endocrinologic 9509062
SDHB 115310 Hyperthyroidism thyrotoxicosis; thyroid gland tumor related endocrinologic 9509062 11404820
SDHB 115310 Psychiatric-disorders psychiatric #12213855 #14715873 #15473885 #16472267
SDHB 115310 Mental-disorders psychiatric #12213855 #14715873 #15473885 #16472267
SDHB 115310 Anxiety-disorders probably hypertension related; worsening anxiety; episodes; anxiety; nervousness; panic psychiatric 12213855 14715873 15473885 16472267
SDHB 115310 Body-temperature-changes miscellaneous #16304664
SDHB 115310 Fever prolonged fever miscellaneous 16304664
SDHB 115310 Cachexia weight loss miscellaneous 14715873
SDHB 115310 Exercise-intolerance fatigue miscellaneous 16304664
SDHB 115310 Catecholamine-levels-abnormal related to paraganglioma of sympathetic origin; noradrenaline elevated; normetanephrine elevated; catecholamine secreting paraganglioma; dopamine levels elevated in urine; dopamin uria miscellaneous 9509062 11404820 12213855 14715873 15371856 15473885 15531530 16258955 16304664 16317055 16405730 16472267

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