Mitochondria Phenome Knowledgebase: Gene ALDH2

Gene Symbol	ALDH2
Ensembl ID	ENSG00000111275	Entrez	217
Gene Alias	ALDH-E2; ALDHI; ALDM; MGC1806	Subcellular Locations	Mitochondria Mitochondrial-matrix
Map Position	12q24.2	Subcell PMIDs	7910607
OMIM Gene	100650	Protein Complex
Swissprot ID	P05091	Swissprot Description	Aldehyde dehydrogenase, mitochondrial precursor
OMIM Disease	Acute alcohol intolerance (AAI) [100650]; Uterine leiomyoma (UL) [150699]; Involutional osteoporosis [166710]

Gene-Feature associations that are associated with 1 Gene

Gene	OMIM Disease	Phenotypic Feature	Phenotype Annotation	Clinical Category	PMIDs
ALDH2	150699	Neoplasms		oncologic	#8521389
ALDH2	150699	Connective-and-soft-tissue-neoplasms		oncologic	#8521389
ALDH2	150699	Muscle-tissue-neoplasm		oncologic	#8521389
ALDH2	150699	Leiomyoma	primary uterine leiomyoma; benign; fusion partners of HMGIC	oncologic	8521389
ALDH2	166710	Musculoskeletal-diseases		musculoskeletal	#16520888
ALDH2	166710	Bone-diseases		musculoskeletal	#16520888
ALDH2	166710	Metabolic-bone-diseases	bone mineral density reduced	musculoskeletal	16520888
ALDH2	166710	Osteoporosis	progressive decline in bone mass; decreased bone mass	musculoskeletal	16520888
ALDH2	166710	Pathological-fractures	increased risk of bone fracture; elderly persons; vertebral fractures; hip fractures	musculoskeletal	16520888
ALDH2	100650	Cardiovascular-diseases		cardiovascular	#10780266
ALDH2	100650	Blood-circulation-disorder	pronounced cardiovascular hemodynamic effects; hemodynamic abnormal	cardiovascular	10780266
ALDH2	100650	Psychiatric-disorders		psychiatric	#10780266 #15654505
ALDH2	100650	Mental-disorders		psychiatric	#10780266 #15654505
ALDH2	100650	Substance-related-disorders	alcohol intolerance; discomfort following alcohol ingestion; susceptibility for alcohol use; susceptibility for tobacco use	psychiatric	10780266 15654505
ALDH2	100650	Cutaneous-flushing	after alcohol intake; intoxication features; alcohol hypersensitivity	miscellaneous	10780266